Recent publications

AgRP neuron activity enhances reward-related consummatory behaviors during energy deficit in mice.
Cassano DA, Barrile F, Reynaldo M, Fernandez G, Cornejo MP, Tolosa MJ, Heredia MF, Ferreira N, Fideles HJ, De Francesco PN, Schiöth HB, Rorato R, Perelló M.
Commun Biol. 2025 Aug 4;8(1):1152. doi: 10.1038/s42003-025-08620-9.

Liraglutide induces enhanced suppression of food intake in mice lacking the growth hormone secretagogue receptor.
Cassano DA, Aguggia J, Giovanini L, Heredia F, De Francesco PN, Andreoli MF, Schöth HB, Habib AM, Fernandez G, Perello M.
Mol Cell Endocrinol. 2025 Oct 1;608:112627. doi: 10.1016/j.mce.2025.112627. Epub 2025 Jul 28.

Selective Colocalization of GHSR and GLP-1R in a Subset of Hypothalamic Neurons and Their Functional Interaction.
Aguggia J, Fernandez G, Cassano D, Mustafá ER, Rodríguez SS, Cantel S, Fehrentz JA, Raingo J, Schiöth HB, Habib AM, De Francesco PN, Perello M.
Endocrinology. 2024 Nov 26;166(1):bqae160. doi: 10.1210/endocr/bqae160.

Growth hormone secretagogue receptor and cannabinoid receptor type 1 intersection in the mouse brain.
Saenz C, Fernandez G, Llovera R, Tolosa MJ, Cantel S, Fehrentz JA, Mackie K, Leggio L, Zigman J, De Francesco PN, Perello M.
Brain Struct Funct. 2024 Dec 19;230(1):15. doi: 10.1007/s00429-024-02876-3.

Hypothalamic tanycytes internalize ghrelin from the cerebrospinal fluid: Molecular mechanisms and functional implications.
Gomez IM, Uriarte M, Fernandez G, Barrile F, Castrogiovanni D, Cantel S, Fehrentz JA, De Francesco PN, Perello M.
Mol Metab. 2024 Dec;90:102046. doi: 10.1016/j.molmet.2024.102046. Epub 2024 Oct 12.

GHSR in a Subset of GABA Neurons Controls Food Deprivation-Induced Hyperphagia in Male Mice.
Cornejo MP, Fernandez G, Cabral A, Barrile F, Heredia F, García Romero G, Zubimendi Sampieri JP, Quelas JI, Cantel S, Fehrentz JA, Alonso A, Pla R, Ferran JL, Andreoli MF, De Francesco PN, Perelló M.
Endocrinology. 2024 May 27;165(7):bqae061. doi: 10.1210/endocr/bqae061.

Pre-prandial plasma liver-expressed antimicrobial peptide 2 (LEAP2) concentration in humans is inversely associated with hunger sensation in a ghrelin independent manner.
Andreoli MF, Fittipaldi AS, Castrogiovanni D, De Francesco PN, Valdivia S, Heredia F, Ribet-Travers C, Mendez I, Fasano MV, Schioth HB, Doi SA, Habib AM, Perello M.
Eur J Nutr. 2024 Apr;63(3):751-762. doi: 10.1007/s00394-023-03304-8. Epub 2023 Dec 29.

Ghrelin Action in the PVH of Male Mice: Accessibility, Neuronal Targets, and CRH Neurons Activation.
Fernandez G, De Francesco PN, Cornejo MP, Cabral A, Aguggia JP, Duque VJ, Sayar N, Cantel S, Burgos JI, Fehrentz JA, Rorato R, Atasoy D, Mecawi AS, Perello M.
Endocrinology. 2023 Sep 23;164(11):bqad154. doi: 10.1210/endocr/bqad154.

Ghrelin’s orexigenic action in the lateral hypothalamic area involves indirect recruitment of orexin neurons and arcuate nucleus activation.
Barrile F, Cassano D, Fernandez G, De Francesco PN, Reynaldo M, Cantel S, Fehrentz JA, Donato J Jr, Schiöth HB, Zigman JM, Perello M.
Psychoneuroendocrinology. 2023 Oct;156:106333. doi: 10.1016/j.psyneuen.2023.106333. Epub 2023 Jul

Ghrelin proteolysis increases in plasma of men, but not women, with obesity.
Fittipaldi AS, Castrogiovanni D, Lufrano D, Saenz C, De Francesco PN, Lalonde T, Luyt LG, Cantel S, Fehrentz JA, Andreoli MF, Perello M.
Life Sci. 2023 Jan 15;313:121305. doi: 10.1016/j.lfs.2022.121305. Epub 2022 Dec 18.

Systemic Ghrelin Treatment Induces Rapid, Transient, and Asymmetric Changes in the Metabolic Activity of the Mouse Brain.
De Francesco PN, Fernandez G, Uriarte M, Urrutia L, Ponce de León M, Fehrentz JA, Falasco G, Perello M.
Neuroendocrinology. 2023;113(1):64-79. doi: 10.1159/000526245. Epub 2022 Jul 29.

The controversial role of the vagus nerve in mediating ghrelin’s actions: gut feelings and beyond
Perelló M, Cornejo MP, De Francesco PN, Fernandez G, Gautron L, Valdivia LS.
IBRO Neurosci Rep. 2022 Mar 12;12:228-239. doi: 10.1016/j.ibneur.2022.03.003. eCollection 2022 Jun.

GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner
Fernandez G, Cabral A, De Francesco PN, Uriarte M, Reynaldo M, Castrogiovanni D, Zubiría G, Giovambattista A, Cantel S, Denoyelle S, Fehrentz JA, Tolle V, Schiöth HB, Perello M.
Cell Mol Life Sci. 2022 May 4;79(5):277. doi: 10.1007/s00018-022-04302-5.

Growth hormone secretagogue receptor signaling in the supramammillary nucleus targets nitric oxide-producing neurons and controls recognition memory in mice
Aguggia JP, Cornejo MP, Fernandez G, De Francesco PN, Mani BK, Cassano D, Cabral A, Valdivia S, García Romero G, Reynaldo M, Fehrentz JA, Zigman JM, Perello M.
Psychoneuroendocrinology. 2022 May;139:105716. doi: 10.1016/j.psyneuen.2022.105716. Epub 2022 Mar 9.

Ghrelin treatment induces rapid and delayed increments of food intake: a heuristic model to explain ghrelin’s orexigenic effects
Cornejo MP, Denis RGP, García Romero G, Fernández G, Reynaldo M, Luquet S, Perello M.
Cell Mol Life Sci. 2021 Oct;78(19-20):6689-6708. doi: 10.1007/s00018-021-03937-0. Epub 2021 Sep 24.

Circulating ghrelin crosses the blood-cerebrospinal fluid barrier via growth hormone secretagogue receptor dependent and independent mechanisms
Uriarte M, De Francesco PN, Fernández G, Castrogiovanni D, D’Arcangelo M, Imbernon M, Cantel S, Denoyelle S, Fehrentz JA, Praetorius J, Prevot V, Perello M.
Mol Cell Endocrinol. 2021 Dec 1;538:111449. doi: 10.1016/j.mce.2021.111449. Epub 2021 Aug 31.

The ups and downs of growth hormone secretagogue receptor signaling.
Cornejo MP, Mustafá ER, Cassano D, Banères JL, Raingo J, Perello M.
FEBS J. 2021 Jan 18. doi: 10.1111/febs.15718. Online ahead of print.