LEAP2
What is the biological role LEAP2?
In 2018, LEAP2 was recognized as another endogenous ligand for GHSR. Our team quickly started to investigate the effects of LEAP2 and we demonstrated that LEAP2 plays an important role not only antagonizing the effect of ghrelin but also acting as an inverse agonist of GHSR.
Now, we are studying what are the LEAP2 targets in the brain and how this peptide affects other edges of GHSR, such as its ability to heterodimerize with other G protein-coupled receptors.