Publicaciones anteriores

The Intriguing Ligand-dependent and Ligand-independent Actions of the Growth Hormone Secretagogue Receptor on Reward-related Behaviors.
Cornejo MP, Mustafá ER, Barrile F, Cassano D, De Francesco PN, Raingo J, Perello M.
Neurosci Biobehav Rev. 2021 Jan;120:401-416. doi: 10.1016/j.neubiorev.2020.10.017. Epub 2020 Nov 4.

Growth hormone secretagogue receptor in dopamine neurons controls appetitive and consummatory behaviors towards high-fat diet in ad-libitum fed mice.
Cornejo MP, Barrile F, Cassano D, Aguggia JP, García Romero G, Reynaldo M, Andreoli MF, De Franceso PN, Perello M.
Psychoneuroendocrinology, 2020 May 22. 2020;119:104718. doi:10.1016/j.psyneuen.2020.104718

Fasting induces remodeling of the orexigenic projections from the arcuate nucleus to the hypothalamic paraventricular nucleus, in a growth hormone secretagogue receptor-dependent manner.
Cabral A, Fernandez G, Tolosa MJ, Rey Moggia A, Calfa G, De Francesco PN, Perello M.
Molecular Metabolism, 2020 Feb;32:69-84. doi:10.1016/j.molmet.2019.11.014. Epub 2019 Dec 16

Plasma levels of ghrelin, des-acyl ghrelin and LEAP2 in children with obesity: correlation with age and insulin resistance.
Fittipaldi AS, Hernández J, Castrogiovanni D, Lufrano D, De Francesco PN, Garrido V, Vitaux P, Fasano MV, Fehrentz J, Fernández A, Andreoli MF, Perello M.
Eur J Endocrinol. 2020;182(2):165-175. doi:10.1530/EJE-19-0684

Development of a novel fluorescent ligand of growth hormone secretagogue receptor based on the N-Terminal Leap2 region.
Barrile F, M’Kadmi C, De Francesco PN, Cabral A, Gracía Romero G, Mustafá ER, Cantel S, Damian M, Mary S, Denoyelle S, Banéres J, Marie J, Raingo J, Fehrentz J, Perello M.
Mol Cell Endocrinol. 2019;498:110573. doi:10.1016/j.mce.2019.110573

Growth hormone secretagogue receptor signalling affects high-fat intake independently of plasma levels of ghrelin and LEAP2, in a 4-day binge eating model.
Cornejo MP, Castrogiovanni D, Schiöth HB, Reynaldo M, Marie J, Fehrentz J, Perello M.
J Neuroendocrinol. 2019;31(10):e12785. doi:10.1111/jne.12785

Inter-individual Variability for High Fat Diet Consumption in Inbred C57BL/6 Mice.
De Francesco PN, Cornejo MP, Barrile F, Gracía Romero G, Valdivia S, Andreoli MF, Perello M.
Front Nutr. 2019;6:67. Published 2019 May 9. doi:10.3389/fnut.2019.00067

Brain accessibility delineates the central effects of circulating ghrelin.
Perello M, Cabral A, Cornejo MP, De Francesco PN, Fernandez G, Uriarte M. J Neuroendocrinol. 2019;31(7):e12677. doi:10.1111/jne.12677

Evidence Supporting a Role for Constitutive Ghrelin Receptor Signaling in Fasting-Induced Hyperphagia in Male Mice.
Fernandez G, Cabral A, Andreoli MF, Labarthe A, M’Kadmi C, Ramos JG, Marie J, Fehrentz JA, Epelbaum J, Tolle V, Perello M.
Endocrinology. 2018 Feb 1;159(2):1021-1034. doi: 10.1210/en.2017-03101.

Ghrelin Recruits Specific Subsets of Dopamine and GABA Neurons of Different Ventral Tegmental Area Sub-nuclei.
Cornejo MP, Barrile F, De Francesco PN, Portiansky EL, Reynaldo M, Perello M.
Neuroscience. 2018;392:107-120. doi:10.1016/j.neuroscience.2018.09.027.

Ghrelin receptor signaling targets segregated clusters of neurons within the nucleus of the solitary tract.
Cornejo MP, De Francesco PN, García Romero G, Portiansky EL, Zigman JM, Reynaldo M, Perello M.
Brain Struct Funct. 2018;223(7):3133-3147. doi:10.1007/s00429-018-1682-5

Evidence Supporting a Role for Constitutive Ghrelin Receptor Signaling in Fasting-Induced Hyperphagia in Male Mice.
Fernandez G, Cabral A, Andreoli MF, Labarthe A, M’Kadmi C, Ramos JG, Marie J, Fehrentz J, Epelbaum J, Tolle V, Perello M.
Endocrinology. 2018;159(2):1021-1034. doi:10.1210/en.2017-03101

A simple strategy for culturing morphologically-conserved rat hypothalamic tanycytes.
De Francesco PN, Castrogiovanni D, Uriarte M, Frassa V, Agosti F, Raingo J, Perello M.
Cell Tissue Res. 2017 Apr 17. doi: 10.1007/s00441-017-2608-x. [Epub ahead of print]

Is Ghrelin Synthesized in the Central Nervous System?
Cabral A, López Soto EJ, Epelbaum J, Perelló M.
Int J Mol Sci. 2017 Mar 15;18(3). pii: E638. doi: 10.3390/ijms18030638. Review.

Circulating Ghrelin Acts on GABA Neurons of the Area Postrema and Mediates Gastric Emptying in Male Mice.
Cabral A, Cornejo MP, Fernandez G, De Francesco PN, Garcia-Romero G, Uriarte M, Zigman JM, Portiansky E, Reynaldo M, Perello M.
Endocrinology. 2017 May 1;158(5):1436-1449. doi: 10.1210/en.2016-1815.

Ghrelin binding to serum albumin and its biological impact.
Lufrano D, Trejo SA, Llovera RE, Salgueiro M, Fernandez G, Martínez Damonte V, González Flecha FL, Raingo J, Ermácora MR, Perelló M.
Mol Cell Endocrinol. 2016 Nov 15;436:130-40. doi: 10.1016/j.mce.2016.07.016. Epub 2016 Jul 16.

Ghrelin activates hypophysiotropic corticotropin-releasing factor neurons independently of the arcuate nucleus.
Cabral A, Portiansky E, Sánchez-Jaramillo E, Zigman JM, Perello M.
Psychoneuroendocrinology. 2016 May;67:27-39. doi: 10.1016/j.psyneuen.2016.01.027. Epub 2016 Feb 1.

Des-Acyl Ghrelin Directly Targets the Arcuate Nucleus in a Ghrelin-Receptor Independent Manner and Impairs the Orexigenic Effect of Ghrelin.
Fernandez G, Cabral A, Cornejo MP, De Francesco PN, Garcia-Romero G, Reynaldo M, Perello M.
J Neuroendocrinol. 2016 Feb;28(2):12349. doi: 10.1111/jne.12349.

Escalation in high fat intake in a binge eating model differentially engages dopamine neurons of the ventral tegmental area and requires ghrelin signaling.
Valdivia S, Cornejo MP, Reynaldo M, De Francesco PN, Perello M.
Psychoneuroendocrinology. 2015 Oct;60:206-16. doi: 10.1016/j.psyneuen.2015.06.018. Epub 2015 Jul 3.

Brain circuits mediating the orexigenic action of peripheral ghrelin: narrow gates for a vast kingdom.
Cabral A, De Francesco PN, Perello M.
Front Endocrinol (Lausanne). 2015 Mar 30;6:44. doi: 10.3389/fendo.2015.00044. eCollection 2015. Review.

Neuroanatomical and functional characterization of CRF neurons of the amygdala using a novel transgenic mouse model.
De Francesco PN, Valdivia S, Cabral A, Reynaldo M, Raingo J, Sakata I, Osborne-Lawrence S, Zigman JM, Perelló M.
Neuroscience. 2015 Mar 19;289:153-65. doi: 10.1016/j.neuroscience.2015.01.006. Epub 2015 Jan 13.

Divergent neuronal circuitries underlying acute orexigenic effects of peripheral or central ghrelin: critical role of brain accessibility.
Cabral A, Valdivia S, Fernandez G, Reynaldo M, Perello M.
J Neuroendocrinol. 2014 Aug;26(8):542-54. doi: 10.1111/jne.12168.

Considerations about rodent models of binge eating episodes.
Perello M, Valdivia S, García Romero G, Raingo J.
Front Psychol. 2014 Apr 29;5:372. doi: 10.3389/fpsyg.2014.00372. eCollection 2014.

Acute high fat diet consumption activates the mesolimbic circuit and requires orexin signaling in a mouse model.
Valdivia S, Patrone A, Reynaldo M, Perello M.
PLoS One. 2014 Jan 23;9(1):e87478. doi: 10.1371/journal.pone.0087478. eCollection 2014.

Analysis of brain nuclei accessible to ghrelin present in the cerebrospinal fluid.
Cabral A, Fernandez G, Perello M.
Neuroscience. 2013 Dec 3;253:406-15. doi: 10.1016/j.neuroscience.2013.09.008. Epub 2013 Sep 13.

Short-term cold exposure activates TRH neurons exclusively in the hypothalamic paraventricular nucleus and raphe pallidus.
Cabral A, Valdivia S, Reynaldo M, Cyr NE, Nillni EA, Perello M.
Neurosci Lett. 2012 Jun 19;518(2):86-91. doi: 10.1016/j.neulet.2012.04.059. Epub 2012 May 2.

Ghrelin indirectly activates hypophysiotropic CRF neurons in rodents.
Cabral A, Suescun O, Zigman JM, Perello M.
PLoS One. 2012;7(2):e31462. doi: 10.1371/journal.pone.0031462. Epub 2012 Feb 20.