Publicaciones recientes

Systemic ghrelin treatment induces rapid, transient and asymmetric changes in the metabolic activity of the mouse brain
De Francesco PN, Fernandez G, Uriarte M, Urrutia L, Ponce de León M, Fehrentz JA, Falasco G, Perello M.
Neuroendocrinology. 2022 Jul 29. doi: 10.1159/000526245. Online ahead of print.

The controversial role of the vagus nerve in mediating ghrelin’s actions: gut feelings and beyond
Perelló M, Cornejo MP, De Francesco PN, Fernandez G, Gautron L, Valdivia LS.
IBRO Neurosci Rep. 2022 Mar 12;12:228-239. doi: 10.1016/j.ibneur.2022.03.003. eCollection 2022 Jun.

GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner
Fernandez G, Cabral A, De Francesco PN, Uriarte M, Reynaldo M, Castrogiovanni D, Zubiría G, Giovambattista A, Cantel S, Denoyelle S, Fehrentz JA, Tolle V, Schiöth HB, Perello M.
Cell Mol Life Sci. 2022 May 4;79(5):277. doi: 10.1007/s00018-022-04302-5.

Growth hormone secretagogue receptor signaling in the supramammillary nucleus targets nitric oxide-producing neurons and controls recognition memory in mice
Aguggia JP, Cornejo MP, Fernandez G, De Francesco PN, Mani BK, Cassano D, Cabral A, Valdivia S, García Romero G, Reynaldo M, Fehrentz JA, Zigman JM, Perello M.
Psychoneuroendocrinology. 2022 May;139:105716. doi: 10.1016/j.psyneuen.2022.105716. Epub 2022 Mar 9.

Ghrelin treatment induces rapid and delayed increments of food intake: a heuristic model to explain ghrelin’s orexigenic effects
Cornejo MP, Denis RGP, García Romero G, Fernández G, Reynaldo M, Luquet S, Perello M.
Cell Mol Life Sci. 2021 Oct;78(19-20):6689-6708. doi: 10.1007/s00018-021-03937-0. Epub 2021 Sep 24.

Circulating ghrelin crosses the blood-cerebrospinal fluid barrier via growth hormone secretagogue receptor dependent and independent mechanisms
Uriarte M, De Francesco PN, Fernández G, Castrogiovanni D, D’Arcangelo M, Imbernon M, Cantel S, Denoyelle S, Fehrentz JA, Praetorius J, Prevot V, Perello M.
Mol Cell Endocrinol. 2021 Dec 1;538:111449. doi: 10.1016/j.mce.2021.111449. Epub 2021 Aug 31.

The ups and downs of growth hormone secretagogue receptor signaling.
Cornejo MP, Mustafá ER, Cassano D, Banères JL, Raingo J, Perello M.
FEBS J. 2021 Jan 18. doi: 10.1111/febs.15718. Online ahead of print.

The Intriguing Ligand-dependent and Ligand-independent Actions of the Growth Hormone Secretagogue Receptor on Reward-related Behaviors.
Cornejo MP, Mustafá ER, Barrile F, Cassano D, De Francesco PN, Raingo J, Perello M.
Neurosci Biobehav Rev. 2021 Jan;120:401-416. doi: 10.1016/j.neubiorev.2020.10.017. Epub 2020 Nov 4.

Growth hormone secretagogue receptor in dopamine neurons controls appetitive and consummatory behaviors towards high-fat diet in ad-libitum fed mice.
Cornejo MP, Barrile F, Cassano D, Aguggia JP, García Romero G, Reynaldo M, Andreoli MF, De Franceso PN, Perello M.
Psychoneuroendocrinology, 2020 May 22. 2020;119:104718. doi:10.1016/j.psyneuen.2020.104718

Fasting induces remodeling of the orexigenic projections from the arcuate nucleus to the hypothalamic paraventricular nucleus, in a growth hormone secretagogue receptor-dependent manner.
Cabral A, Fernandez G, Tolosa MJ, Rey Moggia A, Calfa G, De Francesco PN, Perello M.
Molecular Metabolism, 2020 Feb;32:69-84. doi:10.1016/j.molmet.2019.11.014. Epub 2019 Dec 16

Plasma levels of ghrelin, des-acyl ghrelin and LEAP2 in children with obesity: correlation with age and insulin resistance.
Fittipaldi AS, Hernández J, Castrogiovanni D, Lufrano D, De Francesco PN, Garrido V, Vitaux P, Fasano MV, Fehrentz J, Fernández A, Andreoli MF, Perello M.
Eur J Endocrinol. 2020;182(2):165-175. doi:10.1530/EJE-19-0684

Development of a novel fluorescent ligand of growth hormone secretagogue receptor based on the N-Terminal Leap2 region.
Barrile F, M’Kadmi C, De Francesco PN, Cabral A, Gracía Romero G, Mustafá ER, Cantel S, Damian M, Mary S, Denoyelle S, Banéres J, Marie J, Raingo J, Fehrentz J, Perello M.
Mol Cell Endocrinol. 2019;498:110573. doi:10.1016/j.mce.2019.110573

Growth hormone secretagogue receptor signalling affects high-fat intake independently of plasma levels of ghrelin and LEAP2, in a 4-day binge eating model.
Cornejo MP, Castrogiovanni D, Schiöth HB, Reynaldo M, Marie J, Fehrentz J, Perello M.
J Neuroendocrinol. 2019;31(10):e12785. doi:10.1111/jne.12785

Inter-individual Variability for High Fat Diet Consumption in Inbred C57BL/6 Mice.
De Francesco PN, Cornejo MP, Barrile F, Gracía Romero G, Valdivia S, Andreoli MF, Perello M.
Front Nutr. 2019;6:67. Published 2019 May 9. doi:10.3389/fnut.2019.00067

Brain accessibility delineates the central effects of circulating ghrelin.
Perello M, Cabral A, Cornejo MP, De Francesco PN, Fernandez G, Uriarte M. J Neuroendocrinol. 2019;31(7):e12677. doi:10.1111/jne.12677

Evidence Supporting a Role for Constitutive Ghrelin Receptor Signaling in Fasting-Induced Hyperphagia in Male Mice.
Fernandez G, Cabral A, Andreoli MF, Labarthe A, M’Kadmi C, Ramos JG, Marie J, Fehrentz JA, Epelbaum J, Tolle V, Perello M.
Endocrinology. 2018 Feb 1;159(2):1021-1034. doi: 10.1210/en.2017-03101.

Ghrelin Recruits Specific Subsets of Dopamine and GABA Neurons of Different Ventral Tegmental Area Sub-nuclei.
Cornejo MP, Barrile F, De Francesco PN, Portiansky EL, Reynaldo M, Perello M.
Neuroscience. 2018;392:107-120. doi:10.1016/j.neuroscience.2018.09.027.

Ghrelin receptor signaling targets segregated clusters of neurons within the nucleus of the solitary tract.
Cornejo MP, De Francesco PN, García Romero G, Portiansky EL, Zigman JM, Reynaldo M, Perello M.
Brain Struct Funct. 2018;223(7):3133-3147. doi:10.1007/s00429-018-1682-5

Evidence Supporting a Role for Constitutive Ghrelin Receptor Signaling in Fasting-Induced Hyperphagia in Male Mice.
Fernandez G, Cabral A, Andreoli MF, Labarthe A, M’Kadmi C, Ramos JG, Marie J, Fehrentz J, Epelbaum J, Tolle V, Perello M.
Endocrinology. 2018;159(2):1021-1034. doi:10.1210/en.2017-03101